[Discussion] can we stop arguing about Zepbound until somebody posts a number
Genuinely asking, not being difficult.
Everyone in c/semaglutide repeats that dual agonist is important. I believe it, but I have never seen anyone show why, and when I search I get 6 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
do not crack the pen, we have been over this
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
week 73 on Mounjaro and the appetite profile is genuinely different from sema
the 15mg is the top of the pen, not the required dose
Zepbound and Mounjaro are literally the same drug, the name is the only difference
How long at each step before you escalated?
the dual agonism hits different and that is why people describe it differently
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
Cosigning.
Yes, exactly this, and it is the bit that took me 31 weeks to accept.
Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.
Cosigning.
Adding to this: 15mg is doing more work than the comment implies.
the reflux from tirz is different, not necessarily worse
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
Retitled to remove editorialising. Put the evidence in the body.
Slight fix: the number was 97.6, not 97.9. Decimal point, but a fairly consequential one.
The confident tone is doing a lot of work that the evidence is not.
Half-life is about 168 hours, so steady state lands around week 7–5. Practical consequence: what you feel in week 1 is not what that dose does.
Half-life is about 168 hours, so steady state lands around week 7–5.
Yes, exactly this, and it is the bit that took me 64 weeks to accept.
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
Did the sulphur burps feel the same as on tirz or genuinely different?
week 53 on Mounjaro and the appetite profile is genuinely different from sema
week 53 on Mounjaro and the appetite profile is genuinely different from sema
Yes, exactly this, and it is the bit that took me 96 weeks to accept.
the GIP side does different things than the GLP-1 side, that is the point
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
- 1do not crack the pen, we have been over this9 comments in this branch · started by u/throwaway_titration
- 2Cosigning. The GIP contribution is real and the side effects are not simply…6 comments in this branch · started by u/kofi_balogun