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Single comment threadYou are looking at one branch of [Discussion] can we stop arguing about Zepbound until somebody posts a number — 47 comments in the full submission. View in context.
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c/tirzepatide·submitted 1 year ago by u/incretin_ivy

[Discussion] can we stop arguing about Zepbound until somebody posts a number

Discussionbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/semaglutide repeats that dual agonist is important. I believe it, but I have never seen anyone show why, and when I search I get 6 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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6 comments, started 1 year ago
u/kofi_balogun-5 points·1 year ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/incretin_ivyOPpharmacology1 point·1 year ago

Cosigning.

Yes, exactly this, and it is the bit that took me 31 weeks to accept.

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u/incretin_ivyOPpharmacology1 point·1 year ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/dario_vermeulen1 point·1 year ago

Cosigning.

Adding to this: 15mg is doing more work than the comment implies.

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u/mod_cold_roommod · c/coldchain1 point·1 year ago

the reflux from tirz is different, not necessarily worse

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[deleted]1 point·1 year ago

[deleted]

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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