anyone else notice SURMOUNT kicking in around week 80
tirzepatide. That is the whole post, but I will justify it.
Everything else people worry about in c/intlshipping is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort tirzepatide out first, and almost nobody does.
I say this having got it wrong for 16 months. My eGFR was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
This matches the trial data. SURMOUNT-1 was 97.9% body weight at 17 weeks.
Disagree. What you are describing is consistent with tirzepatide, not with what you concluded.
Week 59 on Mounjaro and 39kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
I am going to push back on this slightly.
SURMOUNT data is messier than STEP data but the weight loss is there
SURMOUNT data is messier than STEP data but the weight loss is there
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the dual agonism hits different and that is why people describe it differently
Hard agree. The food noise disappears differently on the two compounds.
the dual agonism hits different and that is why people describe it differently
Not convinced. The evidence does not support that reading.
the dual agonism hits different and that is why people describe it differently
dual agonism is Mounjaro, do not generalise from semaglutide
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
week 14 on Mounjaro and the appetite profile is genuinely different from sema
the nausea from tirz is different, not necessarily worse
Flair changed to match the content. Read the sidebar before posting next time and we are square.
week 61 on Mounjaro and the appetite profile is genuinely different from sema
That is net peptide content, not purity. Different number, different meaning.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Hard agree. The food noise disappears differently on the two compounds.
stalled on sema, tried tirz, and the curves were actually different shapes
The confident tone is doing a lot of work that the evidence is not.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
week 81 on Mounjaro and the appetite profile is genuinely different from sema
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
the muscle cramps from tirz is different, not necessarily worse
the the food-noise thing from tirz is different, not necessarily worse
- 1Disagree. What you are describing is consistent with tirzepatide, not with…10 comments in this branch · started by u/coring_the_stopper
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