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c/tirzepatide·submitted 1 year ago by u/customs_seizure_sid

anyone else notice SURMOUNT kicking in around week 80

Labbranch of 10 comments

tirzepatide. That is the whole post, but I will justify it. Everything else people worry about in c/intlshipping is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort tirzepatide out first, and almost nobody does. I say this having got it wrong for 16…

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10 comments, started 1 year ago
u/coring_the_stopper1.6k points·1 year ago

Disagree. What you are describing is consistent with tirzepatide, not with what you concluded.

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u/nz_unfunded-14 points·1 year ago

Week 59 on Mounjaro and 39kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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u/nabila_ogunleye-18 points·1 year ago

I am going to push back on this slightly.

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u/kofi_balogun1 point·1 year ago·edited

SURMOUNT data is messier than STEP data but the weight loss is there

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u/thyroid_tangent1 point·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/rania_diallo1 point·1 year ago

the dual agonism hits different and that is why people describe it differently

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u/swirl_dont_shakereconstitution1 point·1 year ago

Hard agree. The food noise disappears differently on the two compounds.

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u/customs_seizure_sid1 point·1 year ago·edited

the dual agonism hits different and that is why people describe it differently

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u/throwaway_wl20261 point·1 year ago

Not convinced. The evidence does not support that reading.

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u/customs_seizure_sidOP705 points·1 year ago

the dual agonism hits different and that is why people describe it differently

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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