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c/t2dglp1·posted 11 months ago by u/aleksi_eriksen

[PSA] glycaemic control is not what most of this community thinks it is

CGM Cold Box ×4 Well Actually ×2

Something I noticed reading old threads that I have not seen said out loud.

The advice on metformin in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

5,714 up / 4,168 down58% upvoted34 commentsid xrs95d14 Aug 2025

34 comments

26 in this archive, depth 4

best — the order this archive was captured in

u/lucia_balogun74 points·11 months ago

hypoglycaemia risk when stacked with A1c

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u/georgi_haddad22 points·11 months ago

hypoglycaemia risk when stacked with A1c

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/baseline_drifteranalytical12 points·11 months ago

hypoglycaemia risk when stacked with metformin

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u/tomas_lundgren3 points·11 months ago

Genuine question — what concentration were you at?

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u/ice_pack_auditcold chain60 points·11 months ago

You have restated the marketing copy. What is the actual substance here.

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u/throwaway_918246 points·11 months ago

type 2 is the indication, weight loss is the side effect

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[removed]33 points·11 months ago

[removed by moderator]

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u/rasmus_kimani48 points·11 months ago

A1c, CGM, stacking with metformin

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u/fasting_insulin_fMOD35 points·11 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/aleksi_eriksenOP16 points·11 months ago

This is an urgent-care question wearing a forum question's clothes.

Yes, exactly this, and it is the bit that took me 91 weeks to accept.

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u/sunday_shot_sal5 points·11 months ago

This is an urgent-care question wearing a forum question's clothes.

Disagree on that part. 98.3% and 98.4% on the same vial is normal.

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u/joaquin_stanescu26 points·11 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/aleksi_eriksenOP19 points·11 months ago

The muscle cramps was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/thandi_solberg7 points·11 months ago

metformin combo is standard

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u/fasting_insulin_f23 points·11 months ago

no medication-stopping advice, ever

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u/fabio_lehtinen-8 points·11 months ago

no medication-stopping advice, ever

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/priya_weiss1 point·11 months ago

A1c, CGM, stacking with metformin

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u/chain_confirm_cpayments1 point·11 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/gustav_lindholm14 points·11 months ago

Australia here. Waited 9 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/wanjiru_osei10 points·11 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/camila_vasquez5 points·11 months ago

type 2 is the indication, weight loss is the side effect

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u/hugo_norgaard2 points·11 months ago

I am going to push back on this slightly.

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u/tomas_lundgren17 points·11 months ago

Strongly agree. A1c matters as much as weight.

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u/gradient_goblin8 points·11 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/emil_okwuosa4 points·11 months ago

hypoglycaemia risk when stacked with A1c

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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