[Discussion] can we stop arguing about glucagon until somebody posts a number
Genuinely asking, not being difficult.
Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 24 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
the 2.5mg arm is different from 1.0mg, results do not transfer
the dosing is steep, the early fullness reports are real, and nobody knows the human safety yet
Small correction: the trial was 7 weeks, not 36. Does not change your point but people will quote it.
Did you actually measure heart rate or is that a feeling?
the 15mg arm is different from 0.25mg, results do not transfer
the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
Respectfully this is a sample of one presented as a finding.
nobody should be giving this to anyone without extensive monitoring
What was the dosing schedule in that arm?
phase 2 numbers are not maintenance numbers, cite the trial
the glucagon component changes the side effect profile, not just the efficacy
the glucagon component changes the side effect profile, not just the efficacy
Yes, exactly this, and it is the bit that took me 5 weeks to accept.
Are you quoting phase 2 or is there phase 3 data now?
nobody should be giving this to anyone without extensive monitoring
Sceptical. If this were true we would see it reflected in the data and we do not.
- 1the dosing is steep, the early fullness reports are real, and nobody knows…8 comments in this branch · started by u/hassan_nilsen
- 2What was the dosing schedule in that arm?6 comments in this branch · started by u/tired_ledger_notes