[Lab] 17th independent test on QSC, and the trend is the interesting part
Long-ish post, sorry. tl;dr at the bottom.
I have been tracking retatrutide against eGFR for 11 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.
Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.
tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.
best — the order this archive was captured in
Flair changed to match the content. Read the sidebar before posting next time and we are square.
You have restated the marketing copy. What is the actual substance here.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
This is correct. Triple agonism is genuinely different.
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
This is correct.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
phase 2 numbers are not maintenance numbers, cite the trial
triple agonism is dose escalation, do not generalise
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
Yes, exactly this, and it is the bit that took me 78 weeks to accept.
the 0.5mg arm is different from 1.0mg, results do not transfer
the 0.5mg arm is different from 1.0mg, results do not transfer
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
phase 2 numbers are not maintenance numbers, cite the trial
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
heart rate and dose escalation need actual measurements, not impressions
Slight fix: the number was 98.6, not 98.7. Decimal point, but a fairly consequential one.
Slight fix: the number was 98.6, not 98.7.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
phase 2 numbers are not maintenance numbers, cite the trial
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Which trial arm and what was the n?
nobody should be giving this to anyone without extensive monitoring
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
This is correct. Triple agonism is genuinely different.
- 1Flair changed to match the content. Read the sidebar before posting next…8 comments in this branch · started by u/incretin_ivy
- 2triple agonism plus glucagon is a different physiological state than…7 comments in this branch · started by u/quiet_moderator