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c/retatrutide·submitted 3 months ago by u/tired_ledger_notes

[Lab] 17th independent test on QSC, and the trend is the interesting part

Labbranch of 7 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against eGFR for 11 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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7 comments, started 3 months ago
u/quiet_moderatormod316 points·3 months ago·edited

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/cold_chromatogram_only203 points·3 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

Yes, exactly this, and it is the bit that took me 78 weeks to accept.

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u/tired_ledger_notesOP119 points·3 months ago

the 0.5mg arm is different from 1.0mg, results do not transfer

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u/trialwatch_theotrial nerd97 points·3 months ago·edited

the 0.5mg arm is different from 1.0mg, results do not transfer

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/reflux_report61 points·3 months ago·edited

phase 2 numbers are not maintenance numbers, cite the trial

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u/emil_agyeman30 points·3 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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[removed]24 points·3 months ago

[removed by moderator]

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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