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c/retatrutide·posted 2 years ago by u/dead_space_doug

is it normal to get the food-noise thing at week 15

Discussion Cold Box ×8 Sourced ×3 Receipts ×3

Been lurking in c/progresspics for about 3 months and finally have something worth posting.

Short version: week 14, 1.7mg, and TRIUMPH is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 17 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 8.

7,930 up / 790 down91% upvoted34 commentsid eutie325 May 2024

34 comments

30 in this archive, depth 4

best — the order this archive was captured in

u/priya_weiss419 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/dead_space_dougOP304 points·2 years ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/priya_weiss184 points·2 years ago

the 0.5mg arm is different from 0.25mg, results do not transfer

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u/quiet_moderatormod50 points·2 years ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/dead_space_dougOP154 points·2 years ago

TRIUMPH phase 2 showed 99.0% weight loss but the injection-site soreness profile on the highest arm was rough. Phase 2 != phase 3.

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[removed]109 points·2 years ago

[removed by moderator]

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u/mateusz_mensah463 points·2 years ago·edited

Are you quoting phase 2 or is there phase 3 data now?

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u/careful_gradient_again671 points·2 years ago

nobody should be giving this to anyone without extensive monitoring

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u/zeynep_mbeki297 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/elodie_grimaldi72 points·2 years ago

Are you quoting phase 2 or is there phase 3 data now?

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u/sena_teixeira101 points·2 years ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/lina_bruun157 points·2 years ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/dead_space_dougOP79 points·2 years ago

TRIUMPH phase 2 showed 97.4% weight loss but the injection-site soreness profile on the highest arm was rough. Phase 2 != phase 3.

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u/trialwatch_theotrial nerd124 points·2 years ago

Respectfully this is a sample of one presented as a finding.

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u/yara_lindholm97 points·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/signe_villalobos59 points·2 years ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/blunt_coldbox_202417 points·2 years ago

Did you actually measure heart rate or is that a feeling?

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u/sena_teixeira7 points·2 years ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/ledger_modMOD24 points·2 years ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/nausea_notesside effects37 points·2 years ago

the dosing is steep, the reflux reports are real, and nobody knows the human safety yet

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u/ewan_marchand8 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/bilal_osei50 points·2 years ago

Disagree. What you are describing is consistent with retatrutide, not with what you concluded.

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u/kofi_balogun27 points·2 years ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/soren_nkemelu39 points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/ismael_eriksen57 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/discount_math_dm12 points·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/endotoxin_elliemicro0 points·2 years ago

research use only, handling and analysis, not protocols

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u/careful_gradient_again1 point·2 years ago

research use only, handling and analysis, not protocols

Disagree on that part. 99.2% and 99.3% on the same vial is normal.

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u/ledger_modmod · vetting0 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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