what changed for me between week 10 and week 59
Been lurking in c/progresspics for about 14 months and finally have something worth posting.
Short version: week 15, 0.5mg, and TRIUMPH is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 37 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 9.
best — the order this archive was captured in
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
This is correct. Triple agonism is genuinely different.
retatrutide is not approved anywhere for human use, posts must not read as instructions
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
heart rate and dose escalation need actual measurements, not impressions
The confident tone is doing a lot of work that the evidence is not.
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
research use only, handling and analysis, not protocols
This is correct. Triple agonism is genuinely different.
Titration speed is a side-effect dial far more than an efficacy dial.
Mechanistically the bit that matters is triple agonist. It explains most of the early profile and a decent chunk of the outcome.
This is correct. Triple agonism is genuinely different.
This is correct.
Yes, exactly this, and it is the bit that took me 81 weeks to accept.
That is net peptide content, not purity. Different number, different meaning.
triple agonism is glucagon, do not generalise
Did you actually measure heart rate or is that a feeling?
- 1Titration speed is a side-effect dial far more than an efficacy dial.7 comments in this branch · started by u/lina_bruun
- 2Dead space in the needle hub holds a small but non-trivial volume. On…6 comments in this branch · started by u/yusuf_ramos