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c/retatrutide·posted 10 months ago by u/source_or_silence

the TRIUMPH thing finally clicked for me and I want to write it down

Results Cold Box ×2 Slow Clap ×3 Long Haul ×3

Right, the triple agonist question again, but with numbers this time.

I have 15 data points over 16 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 70, not week 24. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

5,205 up / 655 down89% upvoted44 commentsid 9ytkh25 Sep 2025

44 comments

22 in this archive, depth 6

best — the order this archive was captured in

u/zeynep_mbeki1k points·10 months ago

the 10mg arm is different from 5mg, results do not transfer

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u/source_or_silence-4 points·10 months ago

Did you actually measure heart rate or is that a feeling?

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u/zeynep_mbeki1 point·10 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/source_or_silenceOP1 point·10 months ago

Did you actually measure heart rate or is that a feeling?

Yes, exactly this, and it is the bit that took me 34 weeks to accept.

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u/hassan_nilsen1 point·10 months ago·edited

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/farid_molnar1 point·10 months ago

the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet

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u/lina_bruun0 points·10 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/sena_teixeira1 point·10 months ago

This is correct. Triple agonism is genuinely different.

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u/emil_wojcik1 point·10 months ago·edited

You have restated the marketing copy. What is the actual substance here.

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u/bilal_osei1 point·10 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/iman_castellanos1 point·10 months ago

triple agonism is phase 2, do not generalise

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[deleted]1 point·10 months ago

[deleted]

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u/honest_syringe_20251 point·10 months ago

phase 2 numbers are not maintenance numbers, cite the trial

Adding to this: triple agonist is doing more work than the comment implies.

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u/jarno_cabrera1 point·10 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/source_or_silenceOP1 point·10 months ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/farid_molnar399 points·10 months ago

This is correct. Triple agonism is genuinely different.

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u/nadia_trevino213 points·10 months ago

Which trial arm and what was the n?

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u/mateusz_mensah245 points·10 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/ewan_marchand77 points·10 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/source_or_silenceOP60 points·10 months ago·edited

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/quiet_moderatormod187 points·10 months ago

Small correction: the trial was 24 weeks, not 16. Does not change your point but people will quote it.

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u/clara_weiss64 points·10 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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