the dose escalation thing finally clicked for me and I want to write it down
Been lurking in c/sideeffects for about 18 months and finally have something worth posting.
Short version: week 46, 12.5mg, and triple agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 23 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 52.
best — the order this archive was captured in
Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.
the 1.0mg arm is different from 7.5mg, results do not transfer
triple agonism is phase 2, do not generalise
This is correct. Triple agonism is genuinely different.
The glucagon component does different things than dual agonism. The the food-noise thing are not just amplified versions.
Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
the 10mg arm is different from 10mg, results do not transfer
Sceptical. If this were true we would see it reflected in the data and we do not.
The glucagon component does different things than dual agonism. The fatigue are not just amplified versions.
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
the dosing is steep, the the food-noise thing reports are real, and nobody knows the human safety yet
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
That is net peptide content, not purity. Different number, different meaning.
TRIUMPH data is phase 2, not phase 3, smaller n and shorter
research use only, handling and analysis, not protocols
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
This is correct. Triple agonism is genuinely different.
the 7.5mg arm is different from 5mg, results do not transfer
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
triple agonism is retatrutide, do not generalise
triple agonism is retatrutide, do not generalise
Yes, exactly this, and it is the bit that took me 73 weeks to accept.
Slight fix: the number was 97.6, not 97.9. Decimal point, but a fairly consequential one.
nobody should be giving this to anyone without extensive monitoring
- 1This is correct. Triple agonism is genuinely different.7 comments in this branch · started by u/incretin_ivy
- 2Three years on this site and the questions have not changed at all. Which is…7 comments in this branch · started by u/trialwatch_theo