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c/retatrutide·submitted 19 days ago by u/yara_lindholm

the dose escalation thing finally clicked for me and I want to write it down

Questionbranch of 7 comments

Been lurking in c/sideeffects for about 18 months and finally have something worth posting. Short version: week 46, 12.5mg, and triple agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 23 threads, and the answers split roughly down the middle. What I actually want…

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7 comments, started 17 days ago
u/incretin_ivypharmacology72 points·17 days ago

This is correct. Triple agonism is genuinely different.

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u/noor_ivaturi26 points·17 days ago

The glucagon component does different things than dual agonism. The the food-noise thing are not just amplified versions.

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u/yara_lindholmOP48 points·17 days ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/rekha_vestergaard14 points·17 days ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/isabela_nilsen3 points·16 days ago

the 10mg arm is different from 10mg, results do not transfer

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u/naomi_erdogan70 points·17 days ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/yara_lindholmOP25 points·17 days ago

The glucagon component does different things than dual agonism. The fatigue are not just amplified versions.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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