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c/retatrutide·submitted 19 days ago by u/yara_lindholm

the dose escalation thing finally clicked for me and I want to write it down

Questionbranch of 7 comments

Been lurking in c/sideeffects for about 18 months and finally have something worth posting. Short version: week 46, 12.5mg, and triple agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 23 threads, and the answers split roughly down the middle. What I actually want…

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7 comments, started 17 days ago
u/trialwatch_theotrial nerd40 points·17 days ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/zeynep_mbeki27 points·17 days ago

the dosing is steep, the the food-noise thing reports are real, and nobody knows the human safety yet

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u/isabela_nilsen18 points·16 days ago·edited

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/yara_lindholmOP11 points·16 days ago

That is net peptide content, not purity. Different number, different meaning.

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u/priya_weiss6 points·16 days ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/tired_ledger_notes3 points·15 days ago

research use only, handling and analysis, not protocols

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u/signe_villalobos10 points·16 days ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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