[Results] 2 weeks, 6kg, and retatrutide was the hard part
phase 2. That is the whole post, but I will justify it.
Everything else people worry about in c/glp1canada is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort phase 2 out first, and almost nobody does.
I say this having got it wrong for 23 months. My ApoB was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
Retitled to remove editorialising. Put the evidence in the body.
Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
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Disagree. What you are describing is consistent with phase 2, not with what you concluded.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet
the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet
Disagree on that part. 99.0% and 98.9% on the same vial is normal.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
retatrutide is not approved anywhere for human use, posts must not read as instructions
triple agonism is phase 2, do not generalise
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
This is correct. Triple agonism is genuinely different.
nobody should be giving this to anyone without extensive monitoring
Not to be pedantic but glucagon and triple agonist are being used interchangeably and they are not interchangeable in real life.
Respectfully this is a sample of one presented as a finding.
triple agonism is dose escalation, do not generalise
This is correct. Triple agonism is genuinely different.
phase 2 numbers are not maintenance numbers, cite the trial
The heart rate signal in TRIUMPH is real and concerning.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the weight curves are unusually steep, which makes predicting individual response harder
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
nobody should be giving this to anyone without extensive monitoring
Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.
Strongly agree. Heart rate escalation needs the actual data, not impressions.
the 1.7mg arm is different from 1.0mg, results do not transfer
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual
- 1triple agonism is phase 2, do not generalise11 comments in this branch · started by u/yusuf_ramos
- 2The practical rule people converge on is 28 days at fridge temperature after…7 comments in this branch · started by u/ledger_mod