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[Question] how do you actually verify goal weight

Question Long Haul ×1 Sourced ×3

Been lurking in c/compounding for about 12 months and finally have something worth posting.

Short version: week 75, 1.7mg, and dose stretching is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 21 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 69.

3,144 up / 593 down84% upvoted44 commentsid 1q7ecc19 Aug 2024

44 comments

30 in this archive, depth 4

best — the order this archive was captured in

u/britt_abubakar166 points·1 year ago

Tried the lowest-effective approach. 12.5mg worked for 19 weeks, then cravings returned. 10mg was the actual floor.

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u/hedda_ekstrom101 points·1 year ago

the long term question changes at maintenance

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u/column_dead_volume-20 points·1 year ago

This is correct. Weight variance is normal at maintenance.

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u/anders_vermeulen194 points·1 year ago

lowest effective dose is lowest effective dose, find it or stay higher

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u/mei_serrano148 points·1 year ago

food noise returns but not always immediately

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u/cold_chromatogram_only0 points·1 year ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/fatima_asante74 points·1 year ago

weight moves within 8kg and that is normal

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u/fatima_yildiz19 points·1 year ago

Slight fix: the number was 96.8, not 95.1. Decimal point, but a fairly consequential one.

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u/santiago_lindqvist48 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/mod_cold_roommod · c/coldchain49 points·1 year ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/laila_almeida40 points·1 year ago

Strongly agree. Lowest effective dose is a real discovery process.

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u/erez_baptista31 points·1 year ago

the lowest dose you can stay on is not the lowest dose that works

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u/rohan_cardoso46 points·1 year ago

the maintenance question changes at maintenance

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u/hassan_ostergaardOP26 points·1 year ago

Regain on a taper is expected. 23% back over 24 weeks, which matches the discontinuation data. Planned for it.

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u/draw_up_dizzy15 points·1 year ago·edited

This is correct. Weight variance is normal at maintenance.

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[removed]7 points·1 year ago

[removed by moderator]

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u/hassan_ostergaardOP32 points·1 year ago

Small correction: the trial was 22 weeks, not 8. Does not change your point but people will quote it.

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u/still_here_202635 points·1 year ago

I am going to push back on this slightly.

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u/nabila_espinoza19 points·1 year ago

weight moves within 21kg and that is normal

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u/hassan_ostergaardOP12 points·1 year ago

Maintenance for 16 months now. 5mg every 12 days, weight 29±16kg. Found the rhythm.

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u/tomas_lokken10 points·1 year ago

regain is not a moral failing

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u/arne_ndiaye6 points·1 year ago

dose-stretching experiences welcome, dose-stretching instructions are not

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u/andres_dahlberg4 points·1 year ago·edited

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/adnan_sandvik9 points·1 year ago

This is correct. Weight variance is normal at maintenance.

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u/nikhil_lindqvist13 points·1 year ago

the lowest dose you can stay on is not the lowest dose that works

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u/still_here_20268 points·1 year ago

Strongly agree. Lowest effective dose is a real discovery process.

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u/britt_abubakar9 points·1 year ago

lowest effective dose is dose stretching, find it or stay higher

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u/sarcopenia_watch13 points·1 year ago

What dose are you on?

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u/milos_vestergaard4 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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u/dario_petrescu13 points·1 year ago

The plateau is real and boring. 90 weeks at the same weight, then movement again. Patience was the intervention.

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About c/maintenancephase

The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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