three years of mechanism threads, summarised so you do not have to read them
Quick one. Canada here.
mechanism works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.
Specifics: the route I used took 13 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.
Happy to answer questions from anyone in the same jurisdiction.
best — the order this archive was captured in
incretin physiology is appetite, the mechanism layer
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rodent mechanism tells you what to investigate, not what to expect in humans
amylin is not GLP-1, posts conflating them get corrected
Half-life is about 168 hours, so steady state lands around week 21–5. Practical consequence: what you feel in week 1 is not what that dose does.
Half-life is about 168 hours, so steady state lands around week 21–5.
Adding to this: incretin is doing more work than the comment implies.
Sceptical. If this were true we would see it reflected in the data and we do not.
glucagon-receptor contribution is pharmacology for dual and triple agonism
The confident tone is doing a lot of work that the evidence is not.
Yeah, the incretin mechanism is doing the work here.
Disagree. What you are describing is consistent with half-life, not with what you concluded.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Stomach physiology changed when I moved up to 1.7mg. Gastric emptying lag is the whole story.
Sceptical.
Yes, exactly this, and it is the bit that took me 80 weeks to accept.
the 10-day half-life means week 10 is still ramp-up pharmacokinetically
rodent receptor tells you what to investigate, not what to expect in humans
do not extrapolate rodent data to human dosing without saying so
- 1Sceptical. If this were true we would see it reflected in the data and we do…11 comments in this branch · started by u/hassan_castellanos
- 2incretin physiology is appetite, the mechanism layer4 comments in this branch · started by u/annika_fonseca