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c/glp1science·submitted 3 months ago by u/bastian_eriksen

three years of mechanism threads, summarised so you do not have to read them

Discussionbranch of 4 comments

Quick one. Canada here. mechanism works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 13 weeks and cost roughly what I expected. The admin was worse than the…

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4 comments, started 3 months ago
u/annika_fonseca219 points·3 months ago

incretin physiology is appetite, the mechanism layer

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[deleted]160 points·3 months ago

[deleted]

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u/second_week_sceptic134 points·3 months ago

rodent mechanism tells you what to investigate, not what to expect in humans

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u/slow_logbook54 points·3 months ago

amylin is not GLP-1, posts conflating them get corrected

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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