three years of mechanism threads, summarised so you do not have to read them
Quick one. Canada here. mechanism works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 13 weeks and cost roughly what I expected. The admin was worse than the…
Sceptical. If this were true we would see it reflected in the data and we do not.
glucagon-receptor contribution is pharmacology for dual and triple agonism
The confident tone is doing a lot of work that the evidence is not.
Yeah, the incretin mechanism is doing the work here.
Disagree. What you are describing is consistent with half-life, not with what you concluded.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Stomach physiology changed when I moved up to 1.7mg. Gastric emptying lag is the whole story.
Sceptical.
Yes, exactly this, and it is the bit that took me 80 weeks to accept.
the 10-day half-life means week 10 is still ramp-up pharmacokinetically
rodent receptor tells you what to investigate, not what to expect in humans
do not extrapolate rodent data to human dosing without saying so