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c/coa·posted 2 years ago by u/ismael_eriksen

switched from 12.5mg to 0.5mg and the muscle cramps got better, not worse

Question Receipts ×3 Cold Box ×1 Slow Clap ×2

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking purity against ApoB for 25 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

3,737 up / 678 down85% upvoted43 commentsid 40b3p018 Nov 2023

43 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/nadia_kjaer208 points·2 years ago

chromatogram or it did not happen

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u/hassan_chowdhury129 points·2 years ago

Cosigning. The batch number is load-bearing information.

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u/emil_agyeman105 points·2 years ago

Not convinced. The evidence does not support that reading.

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[removed]48 points·2 years ago

[removed by moderator]

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u/cesar_ivaturi13 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/joaquin_ivaturi114 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/rohan_steiner46 points·2 years ago

the batch number or it did not happen

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u/dario_vermeulen168 points·2 years ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/ismael_eriksenOP120 points·2 years ago

Tested the GLB raw material and a reseller vial side-by-side. Same purity claim, different impurity profiles. Handling matters.

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u/amira_dumitru100 points·2 years ago

Tested the GLB raw material and a reseller vial side-by-side.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/wanjiru_varga58 points·2 years ago

the method line is doing real work, not just window dressing

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u/ismael_eriksenOP35 points·2 years ago

the counterion is part of the mass you paid for

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u/step_therapy_s22 points·2 years ago

no "is this good?" without saying what the compound and claimed purity are

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u/anecdata_annie42 points·2 years ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/wanjiru_varga25 points·2 years ago·edited

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/anya_correia20 points·2 years ago·edited

the method line is doing real work, not just window dressing

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u/milos_vanhecke16 points·2 years ago

This is the correct framing. The COA structure matters as much as the number.

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u/laila_wojcik6 points·2 years ago·edited

purity and net content are two different numbers, same vial

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u/ismael_eriksenOP-17 points·2 years ago

the method line is doing real work, not just window dressing

Yes, exactly this, and it is the bit that took me 89 weeks to accept.

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u/tidy_vialdrawer_pls1 point·2 years ago

chromatogram or it did not happen

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u/laila_wojcik30 points·2 years ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/tuva_aalto17 points·2 years ago

area% is not mass%, and here is exactly why it matters

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u/elodie_yilmaz18 points·2 years ago

No.

Yes, exactly this, and it is the bit that took me 84 weeks to accept.

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u/sunday_shot_sal51 points·2 years ago

This is the correct framing. The COA structure matters as much as the number.

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u/ignacio_silva38 points·2 years ago

Water content on the document? That affects your concentration math.

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u/foam_head_fred19 points·2 years ago·edited

the batch number or it did not happen

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u/laila_wojcik6 points·2 years ago

Cosigning. The batch number is load-bearing information.

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u/zaid_balogun0 points·2 years ago

the related substances line is where the story is

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u/hassan_chowdhury1 point·2 years ago

post the whole document, not the headline number

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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