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c/cagrilintide·posted 2 months ago by u/laila_dumitru

tried CagriSema for 2 weeks. here is what happened.

Lab Sourced ×3

Genuinely asking, not being difficult.

Everyone in c/hplc repeats that satiety is important. I believe it, but I have never seen anyone show why, and when I search I get 18 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

482 up / 108 down82% upvoted26 commentsid gi13um25 May 2026

26 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/pavel_halvorsen54 points·2 months ago·edited

long-acting amylin is co-agonism, different satiety profile

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u/erez_perrin43 points·2 months ago

Slight fix: the number was 97.4, not 97.2. Decimal point, but a fairly consequential one.

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u/blunt_coldbox36 points·2 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/nadia_fonseca17 points·2 months ago

Not convinced. The evidence does not support that reading.

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u/declared_value_dv11 points·2 months ago

not approved anywhere, keep posts descriptive, not instructional

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[deleted]12 points·2 months ago

[deleted]

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u/aa_analysis_andy5 points·2 months ago·edited

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/erez_perrin5 points·2 months ago

long-acting amylin is co-agonism, different satiety profile

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u/titration_marshalmod · c/semaglutide29 points·2 months ago

tendon and CagriSema literature in rodents is interesting

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u/laila_dumitruOP0 points·2 months ago

Strongly agree. REDEFINE is phase 19, not final.

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u/laila_dumitruOP1 point·2 months ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does satiety.

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u/pavel_halvorsen1 point·2 months ago

CagriSema is a fixed combo in trials, not user-mixed

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u/controversial_only1 point·2 months ago

tendon and REDEFINE literature in rodents is interesting

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u/ilias_kaufmann20 points·2 months ago·edited

That is net peptide content, not purity. Different number, different meaning.

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u/incretin_ivypharmacology11 points·2 months ago

the mechanism is different, the side effect profile reflects it

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u/laila_dumitruOP17 points·2 months ago

REDEFINE phase 2 readouts are interesting but 2 person CagriSema is different from 2 trial CagriSema.

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u/slow_logbook_notes3012 points·2 months ago

CagriSema is a fixed combo in trials, not user-mixed

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u/viktor_erdogan3 points·2 months ago

the mechanism is different, the side effect profile reflects it

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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