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Single comment threadYou are looking at one branch of stalled for 20 weeks at 1.7mg and I refuse to panic this time — 12 comments in the full submission. View in context.
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c/cagrilintide·submitted 2 months ago by u/viktor_erdogan

stalled for 20 weeks at 1.7mg and I refuse to panic this time

Trial Databranch of 6 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking cagrilintide against triglycerides for 31 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one…

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6 comments, started 2 months ago
u/rania_salinas10 points·2 months ago

Are we talking amylin or GLP-1 here?

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u/helga_vermeulen-12 points·2 months ago

the co-agonism question is real and interesting

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u/ferran_halonen1 point·2 months ago·edited

REDEFINE readouts are phase 16 data

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u/micro_bump_mick1 point·2 months ago

amylin receptor distribution is different from GLP-1

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u/slow_logbook_notes301 point·2 months ago

This is correct. The co-agonism is real.

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u/viktor_erdoganOP1 point·2 months ago

REDEFINE phase 3 readouts are interesting but 3 person cagrilintide is different from 3 trial cagrilintide.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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