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c/cagrilintide·posted 2 months ago by u/viktor_erdogan

stalled for 20 weeks at 1.7mg and I refuse to panic this time

Trial Data

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking cagrilintide against triglycerides for 31 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

59 up / 3 down95% upvoted12 commentsid fy1wgo8 May 2026

12 comments

12 in this archive, depth 6

best — the order this archive was captured in

u/rania_salinas10 points·2 months ago

Are we talking amylin or GLP-1 here?

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u/helga_vermeulen-12 points·2 months ago

the co-agonism question is real and interesting

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u/ferran_halonen1 point·2 months ago·edited

REDEFINE readouts are phase 16 data

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u/micro_bump_mick1 point·2 months ago

amylin receptor distribution is different from GLP-1

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u/slow_logbook_notes301 point·2 months ago

This is correct. The co-agonism is real.

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u/viktor_erdoganOP1 point·2 months ago

REDEFINE phase 3 readouts are interesting but 3 person cagrilintide is different from 3 trial cagrilintide.

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u/elin_lundgren10 points·2 months ago

tendon and CagriSema literature in rodents is interesting

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[removed]7 points·2 months ago

[removed by moderator]

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u/nz_unfunded2 points·2 months ago

This is correct. The co-agonism is real.

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u/hedda_aguirre8 points·2 months ago

research use only, no human protocols in posts

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u/solene_abubakar4 points·2 months ago

Strongly agree. REDEFINE is phase 4, not final.

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u/noor_hovland4 points·2 months ago

research use only, no human protocols in posts

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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