u/careful_gradient_again
Keeping a private log and a public opinion.
newer member · joined 22 Jan 2026
Comments — page 4 of 5
comment on [Meta] the data logger rule is doing its job and people should stop complaining in c/coldchain · 28 points · 1 year ago
Customs clearance took 14 days. Package sat unrefrigerated during that. Powder tested clean after, reconstituted solution probably would not have.
comment on what would you tell week-1 you about dose escalation in c/retatrutide · 11 points · 1 year ago
the glucagon component changes the side effect profile, not just the efficacy
comment on [Question] how do you actually verify food noise in c/semaglutide · 25 points · 1 year ago
Slight fix: the number was 99.3, not 93.7. Decimal point, but a fairly consequential one.
comment on three years of SELECT threads, summarised so you do not have to read them in c/trialwatch · 125 points · 1 year ago
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
comment on three years of SELECT threads, summarised so you do not have to read them in c/trialwatch · 1 points · 1 year ago
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
comment on unpopular opinion: semaglutide is massively overrated in c/semaglutide · 1 points · 1 year ago
week 37 and i am still not at maintenance, do not rush the ladder
comment on anyone else notice SURPASS kicking in around week 19 in c/trialwatch · 99 points · 1 year ago
This is correct. Discontinuation arms show the regain reality.
comment on [Vendor] QST order #12 — Denmark, 15 days, no drama, receipts inside in c/semaglutide · 55 points · 1 year ago
You have restated the marketing copy. What is the actual substance here.
comment on three years of triple agonist threads, summarised so you do not have to read them in c/retatrutide · 355 points · 1 year ago
TRIUMPH phase 2 showed 98.3% weight loss but the fatigue profile on the highest arm was rough.
Adding to this: TRIUMPH is doing more work than the comment implies.
comment on failure — my 14-week log, condensed into one table in c/darkspot · 15 points · 1 year ago
This is correct. Evidence still required.
comment on [Discussion] can we stop arguing about endpoint until somebody posts a number in c/trialwatch · 41 points · 1 year ago
Yeah, absolute numbers matter more than the press release.
comment on am I the only one who found cold chain harder than the injections in c/coldchain · 74 points · 1 year ago
stability after excursion is not zero, it is dose-dependent
comment on tried PBS for 8 weeks. here is what happened. in c/glp1aus · 1 points · 1 year ago
What is the PBS status?
comment on tried PBS for 8 weeks. here is what happened. in c/glp1aus · 6 points · 1 year ago
Small correction: the trial was 14 weeks, not 39. Does not change your point but people will quote it.
comment on reading endpoint threads from 2024 and half of it aged badly in c/trialwatch · 421 points · 1 year ago
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
comment on [Vendor] QST order #2 — Spain, 31 days, no drama, receipts inside in c/retatrutide · 32 points · 1 year ago
The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.
comment on [Discussion] the 2.4mg advice in here is 17 years out of date in c/semaglutide · 5 points · 2 years ago
Week 3 for me and the honest summary is: 33kg down, fatigue manageable, and the quiet happened around week 4.
comment on switched from 1.0mg to 2.5mg and the fatigue got better, not worse in c/retatrutide · 25 points · 2 years ago
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
comment on is it normal to get the food-noise thing at week 15 in c/retatrutide · 1 points · 2 years ago
research use only, handling and analysis, not protocols
Disagree on that part. 99.2% and 99.3% on the same vial is normal.
comment on is it normal to get the food-noise thing at week 15 in c/retatrutide · 671 points · 2 years ago
nobody should be giving this to anyone without extensive monitoring