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c/retatrutide·posted 2 years ago by u/customs_seizure_sid

[Vendor] QST order #2 — Spain, 31 days, no drama, receipts inside

Question Well Actually ×4 Slow Clap ×2

Been lurking in c/sideeffects for about 21 months and finally have something worth posting.

Short version: week 96, 12.5mg, and triple agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 35 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 7.

2,206 up / 502 down81% upvoted47 commentsid gstvqv30 Jul 2024

47 comments

19 in this archive, depth 4

best — the order this archive was captured in

u/tired_ledger_notes159 points·1 year ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/incretin_ivyMOD138 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/customs_seizure_sidOP77 points·1 year ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/hugo_pires18 points·1 year ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/rohan_cardoso13 points·1 year ago

heart rate and dose escalation need actual measurements, not impressions

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u/injection_site_iris32 points·1 year ago

Which trial arm and what was the n?

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u/source_or_silence71 points·1 year ago

heart rate and dose escalation need actual measurements, not impressions

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u/tired_ledger_notes87 points·1 year ago

This is correct. Triple agonism is genuinely different.

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u/yusuf_ramos53 points·1 year ago

Are you quoting phase 2 or is there phase 3 data now?

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u/arne_amankwah15 points·1 year ago

nobody should be giving this to anyone without extensive monitoring

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u/ledger_modmod · vetting41 points·1 year ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/careful_gradient_again32 points·1 year ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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[deleted]22 points·1 year ago

[deleted]

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u/lane_watchermod · logistics12 points·1 year ago

the 1.0mg arm is different from 0.5mg, results do not transfer

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u/iman_castellanos10 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/heart_rate_bump3 points·1 year ago

nobody should be giving this to anyone without extensive monitoring

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u/naomi_erdogan15 points·1 year ago

The heart rate signal in TRIUMPH is real and concerning.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/customs_seizure_sidOP11 points·1 year ago

The heart rate signal in TRIUMPH is real and concerning.

Yes, exactly this, and it is the bit that took me 28 weeks to accept.

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u/lurker_for_years6 points·1 year ago

the glucagon component changes the side effect profile, not just the efficacy

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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