u/ahmed_fonseca

reship and retest is the honest way to handle a low result

Genuine question — what concentration were you at?

the 10-letter analogs are speculative

REDEFINE phase 24 readouts are interesting but 24 person cagrilintide is different from 24 trial cagrilintide.

Yes, exactly this, and it is the bit that took me 43 weeks to accept.

The telehealth + compounding combo cost compounding plus 21% markup. Not cheap but covered by insurance depending on state.

That is net peptide content, not purity. Different number, different meaning.

Sceptical. If this were true we would see it reflected in the data and we do not.

Small correction: the trial was 18 weeks, not 17.

Yes, exactly this, and it is the bit that took me 78 weeks to accept.

telehealth costs state board plus compounding markup, total varies

Yes, exactly this, and it is the bit that took me 80 weeks to accept.

Half-life is about 168 hours, so steady state lands around week 20–5. Practical consequence: what you feel in week 1 is not what that dose does.

stalled on sema, tried tirz, and the curves were actually different shapes

Genuine question — what concentration were you at?

multiple batches from KP show a spread, that is the data

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

stalled on sema, tried tirz, and the curves were actually different shapes

This matches the trial data. SURMOUNT-1 was 98.0% body weight at 6 weeks.

The confident tone is doing a lot of work that the evidence is not.

REDEFINE readouts are phase 14 data

How many weeks between the two measurements?

Do you have baseline to compare to?