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c/compounding·posted 1 year ago by u/usp_appendix

[Discussion] the 503A advice in here is 23 years out of date

Discussion

I have had 24 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 32 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 93.7% against a claimed 98.6%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

150 up / 226 down40% upvoted16 commentsid 1mkz5319 Apr 2025

16 comments

16 in this archive, depth 4

best — the order this archive was captured in

u/ahmed_fonseca21 points·1 year ago·edited

The telehealth + compounding combo cost compounding plus 21% markup. Not cheap but covered by insurance depending on state.

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u/lipid_panel_larrybloodwork13 points·1 year ago

Yeah, 503A and 503B are different regulatory animals.

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u/liv_vukovic4 points·1 year ago

the the UK situation is different from the US, different regulations

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u/lift_heavy_thingsresistance training11 points·1 year ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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[removed]8 points·1 year ago

[removed by moderator]

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u/tobias_vukovic2 points·1 year ago

state board rules differ, say which state

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u/usp_appendixcompendial10 points·1 year ago

telehealth costs 503A plus compounding markup, total varies

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u/prior_auth_painMOD4 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/rekha_mwangi2 points·1 year ago

state board rules differ, say which state

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u/usp_appendixOPcompendial3 points·1 year ago

Strongly agree. API source transparency matters.

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u/usp_appendixOPcompendial2 points·1 year ago

The 503A pharmacy I used lost their shortage list eligibility. Same day, compounding became illegal. Rules are real.

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u/elin_ferrari0 points·1 year ago

Did they tell you their API source or dodge the question?

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u/controversial_only0 points·1 year ago

503B compounding is different from 503A, different rules, different legality

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u/usp_appendixOPcompendial1 point·1 year ago

This is correct. The shortage list does expire and the rules change.

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u/camila_sandvik5 points·1 year ago·edited

API source questions are on-topic and compounders dodging them is newsworthy

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u/honest_syringe_20254 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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