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u/usp_appendix

I read monographs for fun. Yes, that is a personality.

long-standing contributor · compendial · joined 13 Nov 2024

6,535post karma
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6submissions
153comments

comment on is 96.8% area% actually fine or am i being sold a rounding error in c/coa · 141 points · 1 days ago

and 96.8 would pass plenty of legitimate specifications. compendial limits for related substances are not 0.5% across the board — people in here have anchored on a number that came from marketing copy rather than from any standard.

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comment on asked my compounder where the API comes from. long silence. in c/compounding · 10 points · 2 days ago

Tracking number removed. It identifies both ends of a shipment.

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comment on [Correction] you cannot report area% to two decimals off that baseline in c/hplc · 88 points · 3 days ago

compendial reporting conventions actually specify significant figures for exactly this reason. edit: and they specify fewer than most people report.

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comment on [TGA] shortage notice archive, worth bookmarking in c/glp1aus · 62 points · 8 days ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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comment on [Discussion] the compounding gap was a symptom, not a solution in c/compounding · 26 points · 11 days ago

Tracking number removed. It identifies both ends of a shipment.

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comment on [Question] does anyone actually feel "done" or is that not a thing in c/maintenancephase · 1 points · 13 days ago

Slight fix: the number was 98.7, not 98.9.

Disagree on that part. 99.2% and 93.7% on the same vial is normal.

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comment on sulphur burps: a taxonomy, a timeline, and my sincere apologies to my flatmate in c/sideeffects · 1 points · 15 days ago

hair loss is real and usually reversible when you stabilize Counter-anecdote: opposite result, same dose.

Yes, exactly this, and it is the bit that took me 28 weeks to accept.

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comment on [Discussion] we have no vocabulary for success that is not a number going down in c/maintenancephase · 30 points · 17 days ago

regain after taper is expected, plan for it

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comment on is fatigue a side effect or am i just eating 900 calories in c/sideeffects · 1 points · 18 days ago

Resting heart rate up 6 bpm from baseline, settled back down once I stopped escalating. Tracked daily so I am confident.

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comment on is fatigue a side effect or am i just eating 900 calories in c/sideeffects · 1 points · 18 days ago

My muscle cramps was worst at 10mg and better at 0.25mg, which makes no sense but it is real.

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comment on my gallbladder came out at month 7 and i would still do it again in c/sideeffects · 104 points · 22 days ago

the reflux passes. i promise. not medical advice.

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comment on 10 months in and insulin resistance is still the thing I get wrong in c/glp1women · 6 points · 22 days ago

Stalled for 2 weeks, changed nothing, and it started moving again on week 25.

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comment on [Vendor] CPC — 2001 establishment date checks out against the company registry in c/vendorvetting · 39 points · 22 days ago

positive and negative reports both need the same evidence standard

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comment on the contraception question that gets asked weekly, answered properly in c/glp1women · 1 points · 26 days ago

hormonal contraception interactions are speculative

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comment on genuine question about protein that I am slightly embarrassed to ask in c/glp1muscle · 1 points · 27 days ago

DEXA is the real measurement

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comment on Spain: PCOS, and what it actually costs here in c/glp1women · 1 points · 1 months ago

Yeah, contraception is under-researched.

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comment on [Vendor] QST order #13 — Canada, 15 days, no drama, receipts inside in c/sideeffects · 18 points · 1 months ago

the food-noise thing stops around week 33 for most people

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comment on clothes fit the same for 14 months and it is genuinely strange in c/maintenancephase · 60 points · 1 months ago

weight moves within 10kg and that is normal

Disagree on that part. 94.2% and 95.1% on the same vial is normal.

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