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c/compounding·posted 1 year ago by u/rekha_mwangi

my TSH moved and I cannot work out whether API source is why

Discussion Clean Column ×9 The Quiet One ×2 Long Haul ×2

Right, the 503A question again, but with numbers this time.

I have 2 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 89, not week 43. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

16,551 up / 12,162 down58% upvoted33 commentsid 1osz4516 Oct 2024

33 comments

25 in this archive, depth 4

best — the order this archive was captured in

u/lukas_delgado603 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/step_count_stan231 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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u/rina_sobczak420 points·1 year ago

the shortage list is temporary, it ends and compounding becomes illegal again

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u/emeka_chowdhury268 points·1 year ago·edited

503B compounding is different from 503A, different rules, different legality

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[removed]434 points·1 year ago

[removed by moderator]

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u/medutest_mel579 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/julia_erdogan722 points·1 year ago

API source questions are on-topic and compounders dodging them is newsworthy

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u/sofia_danquah290 points·1 year ago

shortage list status is compounding, check the actual list

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u/pavel_kravchenko262 points·1 year ago

state board rules differ, say which state

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u/santiago_rasmussen204 points·1 year ago·edited

Disagree. What you are describing is consistent with API source, not with what you concluded.

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u/marit_mwangi371 points·1 year ago·edited

You have restated the marketing copy. What is the actual substance here.

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u/rekha_mwangiOP161 points·1 year ago

The telehealth + compounding combo cost compounding plus 3% markup. Not cheap but covered by insurance depending on state.

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u/joaquin_trevino55 points·1 year ago

You have restated the marketing copy. What is the actual substance here.

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u/vikram_mbeki127 points·1 year ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/teodor_duarte109 points·1 year ago

This is correct. The shortage list does expire and the rules change.

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u/lina_ndiaye37 points·1 year ago

Slight fix: the number was 96.8, not 94.2. Decimal point, but a fairly consequential one.

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u/tobias_vukovic25 points·1 year ago·edited

regulatory claims need a citation to the actual rule, not interpretation

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u/ismael_pires14 points·1 year ago

Strongly agree. API source transparency matters.

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u/ruben_cabrera86 points·1 year ago

Disagree. What you are describing is consistent with 503B, not with what you concluded.

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u/receptor_bias_rick39 points·1 year ago·edited

The 503A pharmacy I used lost their shortage list eligibility. Same day, compounding became illegal. Rules are real.

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u/slow_logbook25 points·1 year ago

API transparency is the question that separates good compounders from sketchy ones

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u/sigrid_kaufmann30 points·1 year ago

API transparency is the question that separates good compounders from sketchy ones

Disagree on that part. 95.1% and 96.2% on the same vial is normal.

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u/mateusz_adebayo67 points·1 year ago

Disagree.

Disagree on that part. 99.2% and 99.3% on the same vial is normal.

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u/nadia_fonseca19 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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  1. Regulatory claims need a citation to the actual rule, notice or docket.
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  3. API source questions are on-topic and pharmacies dodging them is newsworthy.
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