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c/compounding·posted 1 year ago by u/rekha_mwangi

compounding — 17 things I got wrong before I got it right

Question Slow Clap ×7 Receipts ×3 Clean Column ×2

Confession thread, sort of.

I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 8 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have early fullness I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 89 reads it before doing the same thing.

6,162 up / 2,090 down75% upvoted40 commentsid 1muyqs4 Apr 2025

40 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/liver_enzyme_liz480 points·1 year ago

shortage list status is 503A, check the actual list

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u/yannick_petrov-9 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/elise_ramos1 point·1 year ago

the Poland situation is different from the US, different regulations

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u/marit_laurent1 point·1 year ago

Strongly agree. API source transparency matters.

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[removed]1 point·1 year ago

[removed by moderator]

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u/sigrid_kaufmann1 point·1 year ago

the shortage list is temporary, it ends and compounding becomes illegal again

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u/clara_danquah156 points·1 year ago·edited

shortage list status is 503A, check the actual list

Yes, exactly this, and it is the bit that took me 79 weeks to accept.

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u/ismael_pires123 points·1 year ago·edited

the 503A/503B distinction is load-bearing, do not blur it

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u/rekha_mwangiOP48 points·1 year ago

Moved states and the compounding landscape changed completely. Different rules, different pharmacies, different costs.

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u/cold_chromatogram31241 points·1 year ago

the shortage list is temporary, it ends and compounding becomes illegal again

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u/dario_stanescu54 points·1 year ago

the shortage list is temporary, it ends and compounding becomes illegal again

Yes, exactly this, and it is the bit that took me 31 weeks to accept.

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u/julia_erdogan44 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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u/clara_danquah30 points·1 year ago

telehealth prescriber models exist, pricing differs by state

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u/rekha_mwangiOP12 points·1 year ago

Which state? Rules vary.

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u/anya_antonsen162 points·1 year ago

Yeah, 503A and 503B are different regulatory animals.

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u/quiet_moderatorMOD123 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/hugo_bergstrom107 points·1 year ago

This is correct. The shortage list does expire and the rules change.

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u/gustav_cardoso81 points·1 year ago

This is correct.

Disagree on that part. 99.2% and 99.0% on the same vial is normal.

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u/rekha_mwangiOP34 points·1 year ago

This is correct.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/milos_mensa28 points·1 year ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/step_count_stan90 points·1 year ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/camila_sandvik37 points·1 year ago

no pharmacy referral codes, naming is fine, recruiting is not

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u/swirl_dont_shakereconstitution15 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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u/yusuf_kirchner7 points·1 year ago

503B compounding is different from 503A, different rules, different legality

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u/mateusz_adebayo5 points·1 year ago

state board rules differ, say which state

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u/lipid_panel_larrybloodwork22 points·1 year ago

Three years on this site and the questions have not changed at all.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/rina_sobczak14 points·1 year ago

shortage list status is 503B, check the actual list

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u/lift_heavy_thingsresistance training69 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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