u/clara_danquah

the shortage list is temporary, it ends and compounding becomes illegal again

Not to be pedantic but compounding and API source are being used interchangeably and they are not interchangeable in real life.

Flair changed to match the content.

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

instrument quality is less important than analyst consistency

Week 14 or week 15?

Yes, exactly this, and it is the bit that took me 76 weeks to accept.

That is net peptide content, not purity. Different number, different meaning.

a round-robin on baseline integration would be genuinely useful

instrument quality is less important than analyst consistency

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

The related substances profile is way more interesting than the main peak %. A 98% with 9 peaks is different from a 98% that is one 5% impurity.

This is the "correlation is mechanism" thing again. You changed three variables at once.

Mechanistically the bit that matters is 503A. It explains most of the early profile and a decent chunk of the outcome.

This is the correct method framing. Column and gradient are load-bearing fields.

Yeah, the chromatogram profile matters more than the headline number.

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

regulatory status changed in 19 countries, check yours

Yes, exactly this, and it is the bit that took me 59 weeks to accept.

Disagree. What you are describing is consistent with purity, not with what you concluded.

Strongly agree. No question is dumb here.

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.