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c/tirzepatide·posted 1 year ago by u/emil_okwuosa

[Vendor] QST order #20 — Denmark, 39 days, no drama, receipts inside

Lab Cold Box ×9 Long Haul ×1 Receipts ×1

Right, the SURPASS question again, but with numbers this time.

I have 8 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 51, not week 5. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

6,915 up / 1,445 down83% upvoted58 commentsid tex1n11 Mar 2025

58 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/incretin_ivyMOD974 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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[removed]456 points·1 year ago

[removed by moderator]

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u/taper_off_tabitha-34 points·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/mikkel_kimani1 point·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

Disagree on that part. 99.3% and 93.7% on the same vial is normal.

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u/sten_bhattacharya1 point·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing Disagree on that part.

Adding to this: dual agonist is doing more work than the comment implies.

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u/britt_okwuosa896 points·1 year ago

the 15mg is the top of the pen, not the required dose

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u/b12_baseline381 points·1 year ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/coring_the_stopper299 points·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/teodor_szabo243 points·1 year ago·edited

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/emil_okwuosaOP98 points·1 year ago

My ferritin moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/ignacio_vanhecke168 points·1 year ago

the muscle cramps from tirz is different, not necessarily worse

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u/emil_okwuosaOP283 points·1 year ago

do not crack the pen, we have been over this

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u/zeynep_ndiaye76 points·1 year ago

dual agonism is 15mg, do not generalise from semaglutide

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u/zeynep_ndiaye425 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/throwaway_wl2026255 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/ferritin_low63 points·1 year ago

week 66 on Mounjaro and the appetite profile is genuinely different from sema

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u/emil_okwuosaOP108 points·1 year ago

dual agonism is GIP, do not generalise from semaglutide

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u/samir_falk140 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/nordic_pricing43 points·1 year ago·edited

Did the reflux feel the same as on tirz or genuinely different?

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u/ahmed_fonseca272 points·1 year ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/blunt_coldbox29135 points·1 year ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/halima_boateng101 points·1 year ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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u/spain_receta106 points·1 year ago·edited

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/bastian_eriksen36 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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u/hassan_nilsen30 points·1 year ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/piotr_nascimento96 points·1 year ago·edited

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/ferran_mensah66 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/signe_villalobos53 points·1 year ago

Not to be pedantic but SURPASS and SURMOUNT are being used interchangeably and they are not interchangeable in real life.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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