the STEP question that gets asked weekly, answered properly
Been lurking in c/hplc for about 8 months and finally have something worth posting.
Short version: week 83, 10mg, and hazard ratio is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 3 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 89.
best — the order this archive was captured in
Crossposting this to c/hplc because the people who need it are not reading this community.
Strongly agree. Phase 2 is investigational, not conclusive.
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
This is correct. Discontinuation arms show the regain reality.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
phase 2 is not phase 3, smaller n and shorter trial
Not convinced. The evidence does not support that reading.
event rates are more informative than hazard ratios alone
Yeah, absolute numbers matter more than the press release.
the relative risk reduction in headlines is not the whole story
SELECT reported a hazard ratio hazard ratio but the absolute event rate is what changes clinical practice.
- 1This is correct. Discontinuation arms show the regain reality.4 comments in this branch · started by u/slow_logbook_notes30
- 2event rates are more informative than hazard ratios alone4 comments in this branch · started by u/week_four_wall