tried SURPASS for 11 weeks. here is what happened.
Genuinely asking, not being difficult.
Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I search I get 4 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
number-needed-to-treat is the house dialect
press release SELECT posts must be flaired until a publication exists
STEP 1 readout: 96.2% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
STEP 1 readout: 98.9% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
Retitled to remove editorialising. Put the evidence in the body.
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
the discontinuation arms are the interesting part, not the SURPASS endpoints
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
the discontinuation arms are the interesting part, not the TRIUMPH endpoints
the discontinuation arms are the interesting part, not the TRIUMPH endpoints
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
Titration speed is a side-effect dial far more than an efficacy dial.
STEP 1 readout: 97.2% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
Sceptical. If this were true we would see it reflected in the data and we do not.
- 1The practical rule people converge on is 28 days at fridge temperature after…5 comments in this branch · started by u/oskar_ibarra
- 2Water content matters more than people think. If a vial is carrying residual…5 comments in this branch · started by u/rulebook_rachael