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c/trialwatch·posted 1 months ago by u/cold_chromatogram31

[Meta] the endpoint rule is doing its job and people should stop complaining

Press Release Receipts ×1

I have had 11 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 14 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 93.7% against a claimed 94.2%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

468 up / 148 down76% upvoted23 commentsid 13xtbs9 Jun 2026

23 comments

21 in this archive, depth 5

best — the order this archive was captured in

u/yannick_salinas29 points·1 months ago

Yeah, absolute numbers matter more than the press release.

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u/heart_rate_bump26 points·1 months ago·edited
oh thank god it is not just me
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u/aurel_mwangi17 points·1 months ago

the 20 week readout is different from the 22 week readout

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u/yusuf_ramos11 points·1 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/cold_chromatogram31OP16 points·1 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/paper_trail_paulavetting7 points·1 months ago·edited

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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[deleted]5 points·1 months ago

[deleted]

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u/ines_boateng2 points·1 months ago

Is that absolute or relative risk reduction?

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u/cold_chromatogram31OP7 points·1 months ago

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

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u/cold_chromatogram31OP3 points·1 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/anders_karlsen5 points·1 months ago·edited

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/joaquin_trevino7 points·1 months ago

STEP 1 readout: 98.6% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

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u/milan_villalobos5 points·1 months ago·edited

Strongly agree. Phase 2 is investigational, not conclusive.

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u/enzo_ferrari3 points·1 months ago

the relative risk reduction in headlines is not the whole story

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u/forest_plot_fionastats1 point·1 months ago

dropout handling matters, especially on GI-heavy populations

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u/hugo_bergstrom3 points·1 months ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/tomas_kimani1 point·1 months ago

give the trial name, phase, n, and primary endpoint in the body

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u/hazard_ratio_halMOD5 points·1 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/tomas_kimani2 points·1 months ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/sofia_wikstrom1 point·1 months ago

Is that absolute or relative risk reduction?

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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