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c/trialwatch·submitted 1 months ago by u/cold_chromatogram31

[Meta] the endpoint rule is doing its job and people should stop complaining

Press Releasebranch of 7 comments

I have had 11 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 14 days on nominally the same lane, which matters more in summer than in February. The independent number came back 93.7% against a claimed…

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7 comments, started 1 months ago
u/joaquin_trevino7 points·1 months ago

STEP 1 readout: 98.6% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

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u/milan_villalobos5 points·1 months ago·edited

Strongly agree. Phase 2 is investigational, not conclusive.

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u/enzo_ferrari3 points·1 months ago

the relative risk reduction in headlines is not the whole story

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u/forest_plot_fionastats1 point·1 months ago

dropout handling matters, especially on GI-heavy populations

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u/hugo_bergstrom3 points·1 months ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/tomas_kimani1 point·1 months ago

give the trial name, phase, n, and primary endpoint in the body

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