why does nobody talk about hazard ratio
Week 96 update. 22kg down from the start, muscle cramps basically gone since about week 41.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
Half-life is about 168 hours, so steady state lands around week 23–5. Practical consequence: what you feel in week 1 is not what that dose does.
dropout handling matters, especially on GI-heavy populations
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
Not convinced. The evidence does not support that reading.
press release STEP posts must be flaired until a publication exists
dropout handling matters, especially on GI-heavy populations
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
This is correct. Discontinuation arms show the regain reality.
Yeah, absolute numbers matter more than the press release.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
the 5 week readout is different from the 10 week readout
Slight fix: the number was 99.1, not 93.7. Decimal point, but a fairly consequential one.
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
off-label use data is different from approved-indication data
phase 2 is not phase 3, smaller n and shorter trial
This is the "correlation is mechanism" thing again. You changed three variables at once.
the 23 week readout is different from the 24 week readout
number-needed-to-treat is the house dialect
the 23 week readout is different from the 40 week readout
Small correction: the trial was 21 weeks, not 19. Does not change your point but people will quote it.
event rates are more informative than hazard ratios alone
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
Strongly agree. Phase 2 is investigational, not conclusive.
absolute risk reduction, not relative risk reduction, that is how you decide
- 1Half-life is about 168 hours, so steady state lands around week 23–5.…7 comments in this branch · started by u/yusuf_ramos
- 2SURMOUNT-4 discontinuation arm showed regain. That is the reality of a…7 comments in this branch · started by u/britta_boateng