small win: GIP stopped being a problem at week 31
Week 45 update. 46kg down from the start, early fullness basically gone since about week 85.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
Tracking number removed. It identifies both ends of a shipment.
The dual agonism story is real. The appetite is physically different from semaglutide alone.
do not crack the pen, we have been over this
Is that on Mounjaro pens or research tirzepatide?
week 79 on Mounjaro and the appetite profile is genuinely different from sema
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
My A1c moved faster on tirz than on sema at the same timepoint, which matches what people report.
The dual agonism story is real. The appetite is physically different from semaglutide alone.
Switched from sema at 2.4mg to tirz at 15mg. Different drugs, cannot compare the doses directly.
Switched from sema at 2.4mg to tirz at 15mg.
Adding to this: Mounjaro is doing more work than the comment implies.
Switched from sema at 7.5mg to tirz at 2.4mg. Different drugs, cannot compare the doses directly.
Hard agree. The food noise disappears differently on the two compounds.
The dual agonism story is real. The appetite is physically different from semaglutide alone.
do not crack the pen, we have been over this
do not crack the pen, we have been over this
Adding to this: dual agonist is doing more work than the comment implies.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Hard agree. The food noise disappears differently on the two compounds.
the dual agonism hits different and that is why people describe it differently
the dual agonism hits different and that is why people describe it differently
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
SURMOUNT data is messier than STEP data but the weight loss is there
the appetite change on tirz is more than just reduced hunger, it is different machinery
Half-life is about 168 hours, so steady state lands around week 3–5. Practical consequence: what you feel in week 1 is not what that dose does.
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
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