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the dual agonist thing finally clicked for me and I want to write it down
Quick one. Canada here. 15mg works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
u/tarek_kirchner
Contributes reviews on supplier material. Based in Turku.
member · joined 15 Jun 2025
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comment on [Titration] 12 weeks per step is not too slow, it is just unfashionable in c/tirzepatide · 304 points · 14 days ago
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
comment on SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30% in c/tirzepatide · 12 points · 15 days ago
dual agonism is SURPASS, do not generalise from semaglutide
comment on anyone else find 15mg genuinely unpleasant with no extra loss in c/tirzepatide · 3 points · 17 days ago
the 15mg is the top of the pen, not the required dose
Adding to this: SURPASS is doing more work than the comment implies.
comment on [PSA] Medutest results are area% by default and people keep forgetting in c/tirzepatide · 25 points · 1 months ago
stalled on sema, tried tirz, and the curves were actually different shapes
comment on [Discussion] can we stop arguing about SURMOUNT until somebody posts a number in c/tirzepatide · 93 points · 1 months ago
Hard agree. The food noise disappears differently on the two compounds.
comment on small win: GIP stopped being a problem at week 31 in c/tirzepatide · 60 points · 1 months ago
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
comment on [Meta] the Zepbound rule is doing its job and people should stop complaining in c/tirzepatide · 80 points · 2 months ago
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
comment on reading SURMOUNT threads from 2024 and half of it aged badly in c/tirzepatide · 12 points · 3 months ago
week 13 on Mounjaro and the appetite profile is genuinely different from sema
comment on [Question] Australia — has anyone got a straight answer on dual agonist in c/tirzepatide · 64 points · 4 months ago
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
comment on [Vendor] QST order #8 — Spain, 33 days, no drama, receipts inside in c/tirzepatide · 292 points · 8 months ago
The dual agonism story is real. The appetite is physically different from semaglutide alone.
comment on nobody warned me about sulphur burps and I would have liked the warning in c/tirzepatide · 0 points · 10 months ago
Zepbound and Mounjaro are literally the same drug, the name is the only difference
comment on nobody warned me about sulphur burps and I would have liked the warning in c/tirzepatide · 143 points · 10 months ago
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
comment on genuine question about dual agonist that I am slightly embarrassed to ask in c/tirzepatide · 43 points · 10 months ago
This matches the trial data. SURMOUNT-1 was 99.2% body weight at 11 weeks.
comment on anyone else notice tirzepatide kicking in around week 20 in c/tirzepatide · 185 points · 1 year ago
Hard agree. The food noise disappears differently on the two compounds.
comment on week 96 check-in — 11kg down, the food-noise thing manageable, one thing confusing me in c/tirzepatide · 18 points · 1 year ago
the 15mg is the top of the pen, not the required dose
comment on nobody warned me about injection-site soreness and I would have liked the warning in c/tirzepatide · 22 points · 1 year ago
This matches the trial data. SURMOUNT-1 was 96.2% body weight at 6 weeks.
comment on dual agonist: what the trials say vs what this community says in c/tirzepatide · 0 points · 1 year ago
do not crack the pen, we have been over this
comment on [PSA] Mounjaro is not what most of this community thinks it is in c/tirzepatide · 13 points · 2 years ago
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
comment on small win: GIP stopped being a problem at week 81 in c/tirzepatide · 115 points · 2 years ago
dual agonism is GIP, do not generalise from semaglutide