[Question] GIP — what am I missing here
Week 52 update. 13kg down from the start, muscle cramps basically gone since about week 9.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
the appetite change on tirz is more than just reduced hunger, it is different machinery
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week 9 on Mounjaro and the appetite profile is genuinely different from sema
the dual agonism hits different and that is why people describe it differently
the appetite change on tirz is more than just reduced hunger, it is different machinery
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
SURMOUNT data is messier than STEP data but the weight loss is there
SURMOUNT data is messier than STEP data but the weight loss is there
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
Respectfully this is a sample of one presented as a finding.
the GIP side does different things than the GLP-1 side, that is the point
do not crack the pen, we have been over this
Titration speed is a side-effect dial far more than an efficacy dial.
the nausea from tirz is different, not necessarily worse
do not crack the pen, we have been over this
SURMOUNT data is messier than STEP data but the weight loss is there
Hard agree. The food noise disappears differently on the two compounds.
the dual agonism hits different and that is why people describe it differently
Not to be pedantic but tirzepatide and Mounjaro are being used interchangeably and they are not interchangeable in real life.
the appetite change on tirz is more than just reduced hunger, it is different machinery
That is net peptide content, not purity. Different number, different meaning.
Retitled to remove editorialising. Put the evidence in the body.
week 5 on Mounjaro and the appetite profile is genuinely different from sema
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Not to be pedantic but GIP and Zepbound are being used interchangeably and they are not interchangeable in real life.
This matches the trial data. SURMOUNT-1 was 96.2% body weight at 11 weeks.
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
SURMOUNT data is messier than STEP data but the weight loss is there
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
the appetite change on tirz is more than just reduced hunger, it is different machinery
- 1the appetite change on tirz is more than just reduced hunger, it is…13 comments in this branch · started by u/tidy_vialdrawer_pls
- 2SURMOUNT data is messier than STEP data but the weight loss is there6 comments in this branch · started by u/ferran_mensah