[PSA] Mounjaro is not what most of this community thinks it is
Week 70 update. 46kg down from the start, early fullness basically gone since about week 15.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
Half-life is about 168 hours, so steady state lands around week 16–5. Practical consequence: what you feel in week 1 is not what that dose does.
Is that on Mounjaro pens or research tirzepatide?
SURMOUNT data is messier than STEP data but the weight loss is there
Zepbound and Mounjaro are literally the same drug, the name is the only difference
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Yes, exactly this, and it is the bit that took me 42 weeks to accept.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
I am going to push back on this slightly.
SURMOUNT data is messier than STEP data but the weight loss is there
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
the 15mg is the top of the pen, not the required dose
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Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
SURMOUNT data is messier than STEP data but the weight loss is there
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
week 67 on Mounjaro and the appetite profile is genuinely different from sema
the dual agonism hits different and that is why people describe it differently
Week 20 on Mounjaro and 11kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
Flair changed to match the content. Read the sidebar before posting next time and we are square.
the GIP side does different things than the GLP-1 side, that is the point
the GIP side does different things than the GLP-1 side, that is the point
Yes, exactly this, and it is the bit that took me 32 weeks to accept.
do not crack the pen, we have been over this
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
This matches the trial data. SURMOUNT-1 was 99.2% body weight at 24 weeks.
stalled on sema, tried tirz, and the curves were actually different shapes
the early fullness from tirz is different, not necessarily worse
My ApoB moved faster on tirz than on sema at the same timepoint, which matches what people report.
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
the GIP side does different things than the GLP-1 side, that is the point
- 1Inter-lab variance on this kind of assay is routinely 1–2 points. Different…7 comments in this branch · started by u/halima_boateng
- 2This matches the trial data. SURMOUNT-1 was 99.2% body weight at 24 weeks.6 comments in this branch · started by u/sten_bhattacharya