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c/tirzepatide·submitted 2 years ago by u/copay_card_cc

[PSA] Mounjaro is not what most of this community thinks it is

Resultsbranch of 6 comments

Week 70 update. 46kg down from the start, early fullness basically gone since about week 15. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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6 comments, started 2 years ago
u/sten_bhattacharya-22 points·2 years ago

This matches the trial data. SURMOUNT-1 was 99.2% body weight at 24 weeks.

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u/dario_stanescu1 point·2 years ago·edited

stalled on sema, tried tirz, and the curves were actually different shapes

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u/adnan_nascimento1 point·2 years ago

the early fullness from tirz is different, not necessarily worse

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u/copay_card_ccOP1 point·2 years ago

My ApoB moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/gentle_correctionnice about it1 point·2 years ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

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u/fatima_wojcik1 point·2 years ago·edited

the GIP side does different things than the GLP-1 side, that is the point

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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