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c/t2dglp1·posted 3 months ago by u/sten_palacios

glycaemic control: the version I wish someone had shown me in week 1

Caution Clean Column ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: CGM matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 21 months without either producing anything.

What would actually settle it is 7 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

813 up / 76 down91% upvoted57 commentsid ymc6tw15 Apr 2026

57 comments

24 in this archive, depth 4

best — the order this archive was captured in

u/fabio_lehtinen78 points·3 months ago
good post. terrible flair.
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u/jonas_cardoso-17 points·3 months ago

the weight-loss conversation drowns out glycaemic control sometimes

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u/nils_ferreira1 point·3 months ago·edited

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/tomas_kimani23 points·3 months ago·edited

metformin combo is standard

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u/a1c_arcT2D17 points·3 months ago

Strongly agree. A1c matters as much as weight.

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u/runa_grimaldi58 points·3 months ago

Second this question. I have wondered about CGM for 14 months and never seen a straight answer.

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u/teodor_duarte0 points·3 months ago

Strongly agree. A1c matters as much as weight.

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[deleted]1 point·3 months ago

[deleted]

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u/sten_palaciosOP1 point·3 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/kaia_cabrera1 point·3 months ago

the fasting insulin change is the signal

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u/ferran_batista0 points·3 months ago
n=1 but same
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u/ice_pack_auditcold chain1 point·3 months ago

CGM traces tell a story, numbers alone do not

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u/nils_ferreira0 points·3 months ago

Not convinced. The evidence does not support that reading.

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u/freya_onwuka1 point·3 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/gradient_goblin0 points·3 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/tomas_lundgren19 points·3 months ago

This is correct. Hypo risk is real.

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u/gradient_goblin28 points·3 months ago

Not to be pedantic but T2D and metformin are being used interchangeably and they are not interchangeable in real life.

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u/sten_palacios18 points·3 months ago

the fasting insulin change is the signal

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u/neha_falk13 points·3 months ago

the weight-loss conversation drowns out glycaemic control sometimes

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u/fasting_insulin_fMOD9 points·3 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/tired_ledger_notes6 points·3 months ago

This is correct. Hypo risk is real.

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u/sunday_shot_sal7 points·3 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/rui_only_ro2 points·3 months ago·edited

no medication-stopping advice, ever

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u/sten_palaciosOP3 points·3 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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