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c/t2dglp1·posted 7 months ago by u/long_post_larry

anyone else notice hypoglycaemia kicking in around week 40

Question

hypoglycaemia. That is the whole post, but I will justify it.

Everything else people worry about in c/meta is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort hypoglycaemia out first, and almost nobody does.

I say this having got it wrong for 5 months. My hs-CRP was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

133 up / 4 down97% upvoted23 commentsid wobth411 Dec 2025

23 comments

16 in this archive, depth 4

best — the order this archive was captured in

u/adnan_karlsen25 points·7 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/gentle_correctionMOD13 points·7 months ago·edited

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/long_post_larryOP14 points·7 months ago

This is correct. Hypo risk is real.

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u/nadia_norgaard12 points·7 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/hugo_norgaard5 points·7 months ago

glycaemic control first, that is the original indication

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u/lyophile_lou3 points·7 months ago

Which country? Half the answers in this thread only apply in France.

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u/tomas_lundgren-14 points·7 months ago

the A1c change is the signal

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u/hana_lehtinen1 point·7 months ago

Not to be pedantic but metformin and hypoglycaemia are being used interchangeably and they are not interchangeable in real life.

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u/bianca_dziedzic1 point·7 months ago

hypoglycaemia risk when stacked with metformin

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u/emil_okwuosa1 point·7 months ago

hypoglycaemia risk when stacked with A1c

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u/adnan_karlsen1 point·7 months ago

hypoglycaemia risk when stacked with metformin

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/a1c_arcT2D-21 points·7 months ago

no medication-stopping advice, ever

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u/long_post_larryOP1 point·7 months ago

Stalled for 4 weeks, changed nothing, and it started moving again on week 40.

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u/sock_puppet_spotter11 points·7 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/long_post_larryOP7 points·7 months ago

Came off after 77 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/fabio_lehtinen2 points·7 months ago

Not to be pedantic but hypoglycaemia and metformin are being used interchangeably and they are not interchangeable in real life.

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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