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crossposted from c/semaglutide by u/ahmed_abubakar — plateau vs titration — genuinely asking which matters more
Locked. A moderator closed replies on this one. It stays up because the content above the argument is worth keeping.
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c/survodutide·posted 9 months ago by u/elin_ferrari

[Lab] SGN survo — VendorInvestigate came back 99.0% against a claimed 99.1%

Caution Sourced ×7

Posting this because I searched for it and got nothing useful.

Setup: 7.5mg, week 45, constipation present but not ruining anything. I changed exactly one variable — biopsy — and tracked it for 8 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

981 up / 220 down82% upvoted66 commentsid wv7kju5 Oct 2025

66 comments

27 in this archive, depth 5

best — the order this archive was captured in

u/old_account_2023143 points·9 months ago

This is correct. Do not generalise from tirzepatide.

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[removed]103 points·9 months ago

[removed by moderator]

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u/kaia_wojcik52 points·9 months ago·edited

[removed by moderator]

Disagree on that part. 98.1% and 95.1% on the same vial is normal.

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u/hana_pereira108 points·9 months ago

Not convinced. The evidence does not support that reading.

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u/hana_lehtinen90 points·9 months ago

glucagon injection is a different vector than GLP-1

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u/farid_kuipers59 points·9 months ago

Sweden here. Waited 18 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/lyophile_lou21 points·9 months ago

Stalled for 20 weeks, changed nothing, and it started moving again on week 71.

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u/rania_salinas25 points·9 months ago

Sweden here.

Adding to this: biopsy is doing more work than the comment implies.

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u/lyophile_lou6 points·9 months ago

Not to be pedantic but biopsy and survodutide are being used interchangeably and they are not interchangeable in real life.

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u/fibre_forward8 points·9 months ago

glucagon injection is a different vector than GLP-1

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u/border_paperwork-18 points·9 months ago

Strongly agree. The safety story is separate.

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u/kaia_cabrera39 points·9 months ago

Week 84 for me and the honest summary is: 30kg down, reflux manageable, and I have thought about food maybe four times today.

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u/liver_enzyme_lizMOD16 points·9 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/ismael_nwosu5 points·9 months ago

This is an urgent-care question wearing a forum question's clothes.

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

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u/heart_rate_bump10 points·9 months ago

rodent glucagon is investigation only

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u/customs_seizure_sid26 points·9 months ago
post the spreadsheet
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u/refund_ledger6 points·9 months ago

Yeah, glucagon co-agonism is genuinely different.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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