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c/semaglutide·posted 2 years ago by u/ahmed_abubakar

plateau vs titration — genuinely asking which matters more

Meta Clean Column ×5 Well Actually ×1

Something I noticed reading old threads that I have not seen said out loud.

The advice on Ozempic in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

1,835 up / 462 down80% upvoted49 commentsid 1397d816 Apr 2024

49 comments

29 in this archive, depth 5

best — the order this archive was captured in

u/units_not_mgMOD166 points·2 years ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/nikhil_teixeira51 points·2 years ago·edited

stalled at 1.7mg, went up, and regretted it, the stall would have broken anyway

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[removed]68 points·2 years ago

[removed by moderator]

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u/pavel_nkemelu79 points·2 years ago

[removed by moderator]

Yes, exactly this, and it is the bit that took me 86 weeks to accept.

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u/anya_erdogan-4 points·2 years ago

okay but what dose of sema are you on

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u/helga_vermeulen32 points·2 years ago

Hard agree. Week 34 me needed this. Week 83 me is nodding smugly.

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u/vikram_mbeki22 points·2 years ago

Disagree. What you are describing is consistent with food noise, not with what you concluded.

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u/units_not_mgsyringe math108 points·2 years ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/stubborn_batchlist_only89 points·2 years ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/oskar_kaufmann63 points·2 years ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/units_not_mgsyringe math26 points·2 years ago

the 2.4mg dose is not the target, it is just what the pen goes up to

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u/test_it_yourselfvetting137 points·2 years ago

The thing nobody prepared me for was that the appetite does not come back for a long time after you stop.

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u/rina_bergstrom73 points·2 years ago

week 72 and i am still not at maintenance, do not rush the ladder

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u/careful_gradient_again111 points·2 years ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/prior_auth_painappeals70 points·2 years ago

stalled at 2.5mg, went up, and regretted it, the stall would have broken anyway

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u/micro_bump_mick35 points·2 years ago·edited

The thing nobody prepared me for was that the appetite does not come back for a long time after you stop.

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u/katrin_diallo63 points·2 years ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/ewan_tulloch91 points·2 years ago

my eGFR moved before the scale did and i nearly missed it

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u/greta_lokken30 points·2 years ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

Adding to this: semaglutide is doing more work than the comment implies.

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u/archived_thread_a39 points·2 years ago

This is what I tell everyone in c/newbiequestions and they never believe me until week 8.

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u/dead_space_doug18 points·2 years ago

Not convinced. The evidence does not support that reading.

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u/salma_vasquez0 points·2 years ago

week 39 and i am still not at maintenance, do not rush the ladder

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u/zeynep_weiss1 point·2 years ago

Strongly agree. If it is not working at 5mg after 42 weeks, going up is not automatically the answer.

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u/ahmed_abubakarOP1 point·2 years ago

Strongly agree.

Disagree on that part. 97.4% and 96.2% on the same vial is normal.

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u/ferritin_low0 points·2 years ago

stalled at 5mg, went up, and regretted it, the stall would have broken anyway

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u/wanjiru_varga1 point·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/yara_boateng1 point·2 years ago

okay but what dose of sema are you on

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u/kaplan_meier_kim1 point·2 years ago

okay but what dose of sema are you on

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/arne_restrepo1 point·2 years ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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