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c/retatrutide·submitted 5 months ago by u/emil_wojcik

[Lab] 14th independent test on QSC, and the trend is the interesting part

Labbranch of 12 comments

Right, the triple agonist question again, but with numbers this time. I have 19 data points over 4 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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12 comments, started 5 months ago
u/reflux_report192 points·5 months ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/burned_once_twice272 points·5 months ago

Respectfully this is a sample of one presented as a finding.

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u/andres_sorensen184 points·5 months ago

Small correction: the trial was 2 weeks, not 10. Does not change your point but people will quote it.

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u/emil_agyeman265 points·5 months ago

Small correction: the trial was 2 weeks, not 10.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/emil_wojcikOP74 points·5 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/matias_falk-14 points·5 months ago

triple agonism is glucagon, do not generalise

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u/farid_molnar1 point·5 months ago·edited

Slight fix: the number was 97.6, not 97.4. Decimal point, but a fairly consequential one.

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u/viktor_laurent1 point·5 months ago

Slight fix: the number was 97.6, not 97.4.

Yes, exactly this, and it is the bit that took me 8 weeks to accept.

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u/reta_and_regret0 points·5 months ago

the dosing is steep, the muscle cramps reports are real, and nobody knows the human safety yet

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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