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c/retatrutide·submitted 4 months ago by u/emil_wojcik

[Question] dose escalation — what am I missing here

Questionbranch of 6 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on TRIUMPH in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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6 comments, started 4 months ago
u/dead_space_doug24 points·4 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/clara_weiss20 points·4 months ago·edited

Did you actually measure heart rate or is that a feeling?

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u/viktor_laurent15 points·4 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/farid_molnar11 points·4 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/titration_marshalmod · c/semaglutide6 points·4 months ago

This is correct. Triple agonism is genuinely different.

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u/helga_vermeulen8 points·4 months ago

What was the dosing schedule in that arm?

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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