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c/retatrutide·posted 1 months ago by u/careful_gradient_notes

[Discussion] we are measuring retatrutide at the wrong time and calling it noise

Discussion

Genuinely asking, not being difficult.

Everyone in c/glp1uk repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 20 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

242 up / 74 down77% upvoted20 commentsid tydh6u20 Jun 2026

20 comments

14 in this archive, depth 5

best — the order this archive was captured in

u/sena_teixeira16 points·1 months ago

research use only, handling and analysis, not protocols

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u/arne_amankwah4 points·1 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/trialwatch_theoMOD11 points·1 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/nadia_trevino5 points·1 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/reflux_report10 points·1 months ago

Half-life is about 168 hours, so steady state lands around week 17–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/careful_gradient_notesOP5 points·1 months ago

Are you quoting phase 2 or is there phase 3 data now?

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[deleted]4 points·1 months ago

[deleted]

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u/andres_sorensen6 points·1 months ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/rohan_cardoso3 points·1 months ago

Not convinced. The evidence does not support that reading.

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u/andres_restrepo-34 points·1 months ago

This is correct. Triple agonism is genuinely different.

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u/matias_falk8 points·1 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/mod_cold_roommod · c/coldchain9 points·1 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/titration_marshalmod · c/semaglutide6 points·1 months ago

research use only, handling and analysis, not protocols

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u/nikhil_asante5 points·1 months ago

Are you quoting phase 2 or is there phase 3 data now?

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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