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c/retatrutide·posted 2 years ago by u/naomi_erdogan

week 56 check-in — 46kg down, early fullness manageable, one thing confusing me

Caution Receipts ×3 Cold Box ×1 Sourced ×2

I have had 21 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 22 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 93.7% against a claimed 98.6%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

4,951 up / 598 down89% upvoted61 commentsid f4t43210 May 2024

61 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/ledger_modmod · vetting403 points·2 years ago

Titration speed is a side-effect dial far more than an efficacy dial.

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[removed]149 points·2 years ago

[removed by moderator]

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u/viktor_laurent116 points·2 years ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/trialwatch_theotrial nerd64 points·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/yara_lindholm75 points·2 years ago

research use only, handling and analysis, not protocols

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u/helga_vermeulen-37 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/careful_gradient_again362 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/yannick_barros178 points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/careful_gradient_again62 points·2 years ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/trialwatch_theotrial nerd119 points·2 years ago·edited

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/nordic_pricing39 points·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/jarno_cabrera531 points·2 years ago

Respectfully this is a sample of one presented as a finding.

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u/customs_seizure_sid106 points·2 years ago

The glucagon component does different things than dual agonism. The nausea are not just amplified versions.

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u/source_or_silence82 points·2 years ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/tired_ledger_notes43 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/niels_lindqvist34 points·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/vito_beaulieu16 points·2 years ago

Did you actually measure heart rate or is that a feeling?

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u/trialwatch_theoMOD211 points·2 years ago

Tracking number removed. It identifies both ends of a shipment.

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u/nikhil_lindqvist167 points·2 years ago

TRIUMPH phase 2 showed 98.0% weight loss but the fatigue profile on the highest arm was rough. Phase 2 != phase 3.

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u/devils_advocate_d56 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/vito_beaulieu157 points·2 years ago
genuinely useful, thanks
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u/reflux_report0 points·2 years ago

Slight fix: the number was 99.3, not 93.7. Decimal point, but a fairly consequential one.

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u/naomi_erdoganOP1 point·2 years ago

TRIUMPH phase 2 showed 99.0% weight loss but the reflux profile on the highest arm was rough. Phase 2 != phase 3.

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u/sofia_wikstrom0 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/tired_ledger_notes1 point·2 years ago

Slight fix: the number was 97.6, not 98.1. Decimal point, but a fairly consequential one.

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u/renzo_yildiz1 point·2 years ago

Slight fix: the number was 97.6, not 98.1.

Yes, exactly this, and it is the bit that took me 58 weeks to accept.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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